Sienna to Casalnuovo di Napoli trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Casalnuovo di Napoli every about 2 hours on average. If travelling with Trenitalia, you need to know the Sienna to Casalnuovo di Napoli train schedule: the first train leaves at 07:15, while the last ride is at 15:18. A Sienna to Casalnuovo di Napoli train cost about 58.0 €. But how long is the train ride from Sienna to Casalnuovo di Napoli? Your journey takes about 6 hours on average.