Sienna to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Castelvetrano every about 6 hours on average. If travelling with Trenitalia, you need to know the Sienna to Castelvetrano train schedule: the first train leaves at 18:02, while the last ride is at 18:43. A Sienna to Castelvetrano train cost about 140.05 €. But how long is the train ride from Sienna to Castelvetrano? Your journey takes about 21 hours on average.