Sienna to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Comiso every about 6 hours on average. If travelling with Trenitalia, you need to know the Sienna to Comiso train schedule: the first train leaves at 17:43, while the last ride is at 17:46. A Sienna to Comiso train cost about 159.6 €. But how long is the train ride from Sienna to Comiso? Your journey takes about 19 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Comiso and find low cost tickets starting from 72 €!