Sienna to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Sienna to Messina train schedule: the first train leaves at 07:15, while the last ride is at 21:26. A Sienna to Messina train cost about 89.2 €. But how long is the train ride from Sienna to Messina? Your journey takes about 13 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Messina and find low cost tickets starting from 106 €!