Sienna to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Sienna to Palermo train schedule: the first train leaves at 17:43, while the last ride is at 21:26. A Sienna to Palermo train cost about 95.55 €. But how long is the train ride from Sienna to Palermo? Your journey takes about 20 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Palermo and find low cost tickets starting from 32 €!