Vicenza to Sienna trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Vicenza and arrive at Siena every 60 minutes on average. If travelling with Trenitalia, you need to know the Vicenza to Sienna train schedule: the first train leaves at 08:26, while the last ride is at 23:02. A Vicenza to Sienna train cost about 45.8 €. But how long is the train ride from Vicenza to Sienna? Your journey takes about 5 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Vicenza to Sienna and find low cost tickets starting from 23 €!