Travel from Manduria to Isernia and discover this Molise city of 17.000 inhabitants. The distance from Manduria to Isernia is 506 kilometers; with Wanderio you can compare the available trains to get from Manduria to Isernia, so that you can organize your trip choosing the fastest route, the most comfortable or the cheapest one. You can choose among different choices and organize your trip according to your needs, depending on whether you are looking for the fastest, the most comfortable or perhaps the cheapest travel solution. For example, by choosing a train from Manduria to Isernia, you’ll get to your destination in about 6 hours on average; train ticket prices start from 25 €.