Considering there is a distance of 923 km between these two cities, taking a flight to get from Rome to Prague is a good option, as the average trip duration is about 2 hours. You can find up to 53 daily connections between your departure city and Prague, 5 of which are direct flights. </br></br><strong> The departure airport </strong></br> Rome main airport is Rome Fiumicino Airport, which is 22 km away from the centre. 52 flights to Prague leave from here everyday, from 06:20 to 23:05. These flights are operated by companies like Lufthansa, Aeroflot, Brussels Airlines. You can take a shuttle bus from Rome to Rome Fiumicino Airport to get to the airport purchasing the tickets together with the air tickets online on Wanderio. Thanks to our service, in fact, you can compare all the available airlines and find other means of transport to organize your trip, such as the transfers to get to the airport or to your destination. </br> Another airport to start your journey from is Rome Ciampino Airport, which is served by Wizz Air. The first take-off is at 13:05 while the last one occurs at 13:05; to get to the airport, that is 13 km distant, you can take a transfer to Rome Ciampino Airport from Rome. </br></br><strong> The arrival airport </strong></br> If you’re going from Rome to Prague by plane, you will land at Prague Airport , or, based on the company operating the flight, at Pardubice Airport, Karlovy Vary Airport . The main airport is 10 km away from the centre and can be easily reached by taking a shuttle bus from Prague Airport to Prague. However, in case you land elsewhere, you can find transfers from your arrival airport to your destination on Wanderio.