Travel from Milan to Palermo and discover this Sicilia city of 650.000 inhabitants. The distance from Milan to Palermo is 1420 kilometers; with Wanderio you can compare the available trains, buses, and flights to get from Milan to Palermo, so that you can organize your trip choosing the fastest route, the most comfortable or the cheapest one. You can choose among different choices and organize your trip according to your needs, depending on whether you are looking for the fastest, the most comfortable or perhaps the cheapest travel solution. For example, by choosing a flight from Milan to Palermo, you’ll get to your destination in about 2 hours on average; flight ticket prices start from 91 €. Going from Milan to Palermo by train instead? Prices for your ticket start from 69 € and the train journey takes about 15 hours on average.