Travel from Rome to Palermo and discover this Sicilia city of 650.000 inhabitants. The distance from Rome to Palermo is 683 kilometers; with Wanderio you can compare the available flights, buses, and trains to get from Rome to Palermo, so that you can organize your trip choosing the fastest route, the most comfortable or the cheapest one. You can choose among different choices and organize your trip according to your needs, depending on whether you are looking for the fastest, the most comfortable or perhaps the cheapest travel solution. For example, by choosing a flight from Rome to Palermo, you’ll get to your destination in about 1 hour on average; flight ticket prices start from 46 €. Going from Rome to Palermo by train instead? Prices for your ticket start from 43 € and the train journey takes about 10 hours on average.