Acqui Terme to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Acqui Terme and arrive at Comiso every about 2 hours on average. If travelling with Trenitalia, you need to know the Acqui Terme to Comiso train schedule: the first train leaves at 09:42, while the last ride is at 20:49. A Acqui Terme to Comiso train cost about 122.65 €. But how long is the train ride from Acqui Terme to Comiso? Your journey takes about 5 hours on average.