Alessandria to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Alessandria and arrive at Comiso every about 4 hours on average. If travelling with Trenitalia, you need to know the Alessandria to Comiso train schedule: the first train leaves at 20:31, while the last ride is at 22:59. A Alessandria to Comiso train cost about 92.1 €. But how long is the train ride from Alessandria to Comiso? Your journey takes about 24 hours on average.