Alessandria to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Alessandria and arrive at Milazzo every about 2 hours on average. If travelling with Trenitalia, you need to know the Alessandria to Milazzo train schedule: the first train leaves at 13:31, while the last ride is at 22:59. A Alessandria to Milazzo train cost about 111.5 €. But how long is the train ride from Alessandria to Milazzo? Your journey takes about 17 hours on average.