Alessandria to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Alessandria and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Alessandria to Syracuse train schedule: the first train leaves at 13:31, while the last ride is at 22:59. A Alessandria to Syracuse train cost about 115.6 €. But how long is the train ride from Alessandria to Syracuse? Your journey takes about 19 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Alessandria to Syracuse and find low cost tickets starting from 87 €!