Avezzano to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Avezzano and arrive at Messina Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Avezzano to Messina train schedule: the first train leaves at 06:56, while the last ride is at 19:10. A Avezzano to Messina train cost about 45.3 €. But how long is the train ride from Avezzano to Messina? Your journey takes about 12 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Avezzano to Messina and find low cost tickets starting from 36 €!