Casa Santa to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Trapani and arrive at Comiso every about 12 hours on average. If travelling with Trenitalia, you need to know the Casa Santa to Comiso train schedule: the first train leaves at 05:43, while the last ride is at 05:43. A Casa Santa to Comiso train cost about 20.6 €. But how long is the train ride from Casa Santa to Comiso? Your journey takes about 13 hours on average.