Casalecchio di Reno to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casalecchio di Reno and arrive at Niscemi every about 2 hours on average. If travelling with Trenitalia, you need to know the Casalecchio di Reno to Niscemi train schedule: the first train leaves at 09:40, while the last ride is at 22:14. A Casalecchio di Reno to Niscemi train cost about 103.15 €. But how long is the train ride from Casalecchio di Reno to Niscemi? Your journey takes about 10 hours on average.