Casalnuovo di Napoli to Brindisi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casalnuovo di Napoli and arrive at Brindisi every about 3 hours on average. If travelling with Trenitalia, you need to know the Casalnuovo di Napoli to Brindisi train schedule: the first train leaves at 08:31, while the last ride is at 18:34. A Casalnuovo di Napoli to Brindisi train cost about 49.2 €. But how long is the train ride from Casalnuovo di Napoli to Brindisi? Your journey takes about 5 hours on average.