Città di Castello to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Firenze S. M. Novella, Rimini, Arezzo and arrive at Torino Porta Nuova, Milano Rogoredo, Milano Centrale, Alessandria every 10 minutes on average. If travelling with Trenitalia, you need to know the Città di Castello to Alessandria train schedule: the first train leaves at 00:40, while the last ride is at 22:28. A Città di Castello to Alessandria train cost about 18.25 €. But how long is the train ride from Città di Castello to Alessandria? Your journey takes about 4 hours on average. Trenitalia offers 22 direct trains between these two cities. If you need to travel this week, prices start from 36.50€ to a maximum price of 117.90€. When booking your train ticket a few weeks in advance though, you can find low cost trains from Città di Castello to Alessandria with fares starting from 18.25€, saving up to 58%.