Città di Castello to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Arezzo, Salerno and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Città di Castello to Messina train schedule: the first train leaves at 07:25, while the last ride is at 22:53. A Città di Castello to Messina train cost about 74.95 €. But how long is the train ride from Città di Castello to Messina? Your journey takes about 13 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Città di Castello to Messina and find low cost tickets starting from 49 €! If you need to travel this week, prices start from 45.50€.