Città di Castello to Syracuse trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Città di Castello to Syracuse. Trains leave from Arezzo and arrive at Siracusa every about 6 hours on average. The trip by train from Città di Castello to Syracuse last on average 15:20 travelling with high-speed trains (Frecciarossa or Italotreno) If travelling with Trenitalia, you need to know the Città di Castello to Syracuse train schedule: the first train leaves at 07:25, while the last ride is at 08:43. A Città di Castello to Syracuse train cost about 109.5 €. But how long is the train ride from Città di Castello to Syracuse? Your journey takes about 15 hours on average.