Città di Castello to Syracuse trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Città di Castello to Syracuse. The first train to Syracuse leaves from Città di Castello at 07:25 and the last train departs at 08:43. The trip by train from Città di Castello to Syracuse last on average 15:20 travelling with high-speed trains (Frecciarossa or Italotreno) If you choose a local train the trip lasts on average 14:02 hours. For your trip from Città di Castello to Syracuse by train you can choose to leave from one of Città di Castello main stations: Arezzo On Wanderio you can compare all schedules, fares and railway companies to Syracuse and book the best itinerary starting from Città di Castello.