Comiso to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Comiso and arrive at Alessandria every about 4 hours on average. If travelling with Trenitalia, you need to know the Comiso to Alessandria train schedule: the first train leaves at 07:09, while the last ride is at 18:22. A Comiso to Alessandria train cost about 123.7 €. But how long is the train ride from Comiso to Alessandria? Your journey takes about 16 hours on average.