Comiso to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Comiso and arrive at Alessandria every about 4 hours on average. If travelling with Trenitalia, you need to know the Comiso to Alessandria train schedule: the first train leaves at 07:09, while the last ride is at 18:22. A Comiso to Alessandria train cost about 123.7 €. But how long is the train ride from Comiso to Alessandria? Your journey takes about 16 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Comiso to Alessandria and find low cost tickets starting from 79 €!