Crema to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Crema and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Crema to Messina train schedule: the first train leaves at 06:25, while the last ride is at 20:25. A Crema to Messina train cost about 74.5 €. But how long is the train ride from Crema to Messina? Your journey takes about 16 hours on average.