Crema to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Crema and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Crema to Niscemi train schedule: the first train leaves at 19:25, while the last ride is at 19:25. A Crema to Niscemi train cost about 185.55 €. But how long is the train ride from Crema to Niscemi? Your journey takes about 2 hours on average.