Crema to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Crema and arrive at Siracusa every about 3 hours on average. If travelling with Trenitalia, you need to know the Crema to Syracuse train schedule: the first train leaves at 06:25, while the last ride is at 20:25. A Crema to Syracuse train cost about 74.5 €. But how long is the train ride from Crema to Syracuse? Your journey takes about 19 hours on average.