Desio to Caltagirone trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desio and arrive at Caltagirone every about 2 hours on average. If travelling with Trenitalia, you need to know the Desio to Caltagirone train schedule: the first train leaves at 07:24, while the last ride is at 22:15. A Desio to Caltagirone train cost about 112.4 €. But how long is the train ride from Desio to Caltagirone? Your journey takes about 7 hours on average.