Domodossola to Lecce trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Lecce every about 2 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Lecce train schedule: the first train leaves at 04:54, while the last ride is at 18:54. A Domodossola to Lecce train cost about 82.0 €. But how long is the train ride from Domodossola to Lecce? Your journey takes about 12 hours on average.