Empoli to Alpignano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Empoli and arrive at Alpignano every 60 minutes on average. If travelling with Trenitalia, you need to know the Empoli to Alpignano train schedule: the first train leaves at 01:15, while the last ride is at 17:04. A Empoli to Alpignano train cost about 42.35 €. But how long is the train ride from Empoli to Alpignano? Your journey takes about 6 hours on average.