Empoli to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Empoli and arrive at Caltanissetta Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Empoli to Caltanissetta train schedule: the first train leaves at 19:32, while the last ride is at 22:33. A Empoli to Caltanissetta train cost about 78.1 €. But how long is the train ride from Empoli to Caltanissetta? Your journey takes about 19 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Empoli to Caltanissetta and find low cost tickets starting from 74 €!