Empoli to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Empoli and arrive at Caltanissetta Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Empoli to Caltanissetta train schedule: the first train leaves at 19:32, while the last ride is at 22:33. A Empoli to Caltanissetta train cost about 78.1 €. But how long is the train ride from Empoli to Caltanissetta? Your journey takes about 19 hours on average.