Empoli to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Empoli and arrive at Castelvetrano every about 1 hour on average. If travelling with Trenitalia, you need to know the Empoli to Castelvetrano train schedule: the first train leaves at 06:01, while the last ride is at 22:33. A Empoli to Castelvetrano train cost about 102.15 €. But how long is the train ride from Empoli to Castelvetrano? Your journey takes about 15 hours on average.