Empoli to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Empoli and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Empoli to Messina train schedule: the first train leaves at 01:15, while the last ride is at 22:33. A Empoli to Messina train cost about 64.3 €. But how long is the train ride from Empoli to Messina? Your journey takes about 12 hours on average.