Empoli to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Empoli and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Empoli to Messina train schedule: the first train leaves at 01:15, while the last ride is at 22:33. A Empoli to Messina train cost about 64.3 €. But how long is the train ride from Empoli to Messina? Your journey takes about 12 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Empoli to Messina and find low cost tickets starting from 92 €!