Florence to Agrigento trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Firenze S. M. Novella and arrive at Agrigento Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Florence to Agrigento train schedule: the first train leaves at 20:38, while the last ride is at 20:38. A Florence to Agrigento train cost about 125.25 €. But how long is the train ride from Florence to Agrigento? Your journey takes about 17 hours on average.