Frosinone to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Frosinone and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Frosinone to Messina train schedule: the first train leaves at 05:41, while the last ride is at 19:20. A Frosinone to Messina train cost about 44.90 €. But how long is the train ride from Frosinone to Messina? Your journey takes about 10 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Frosinone to Messina and find low cost tickets starting from 49 €!