Frosinone to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Frosinone and arrive at Niscemi every about 4 hours on average. If travelling with Trenitalia, you need to know the Frosinone to Niscemi train schedule: the first train leaves at 05:41, while the last ride is at 20:23. A Frosinone to Niscemi train cost about 84.65 €. But how long is the train ride from Frosinone to Niscemi? Your journey takes about 17 hours on average.