Guidonia to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Guidonia-Montecelio-S. Angelo and arrive at Siracusa every about 6 hours on average. If travelling with Trenitalia, you need to know the Guidonia to Syracuse train schedule: the first train leaves at 06:15, while the last ride is at 20:35. A Guidonia to Syracuse train cost about 76.6 €. But how long is the train ride from Guidonia to Syracuse? Your journey takes about 13 hours on average.