Isernia to Acireale trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia, Napoli Centrale and arrive at Acireale, Reggio di Calabria Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Isernia to Acireale train schedule: the first train leaves at 06:45, while the last ride is at 23:53. A Isernia to Acireale train cost about 63.30 €. But how long is the train ride from Isernia to Acireale? Your journey takes about 12 hours on average. If you need to travel this week, prices start from 79.10€.