Isernia to Acireale trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 4 daily rides to get from Isernia to Acireale. Trains leave from Isernia,Napoli Centrale and arrive at Acireale,Reggio di Calabria Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Isernia to Acireale train schedule: the first train leaves at 06:45, while the last ride is at 23:53. A Isernia to Acireale train cost about 57.45 €. But how long is the train ride from Isernia to Acireale? Your journey takes about 12 hours on average.