Isernia to Agrigento trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Agrigento Bassa every about 6 hours on average. If travelling with Trenitalia, you need to know the Isernia to Agrigento train schedule: the first train leaves at 07:27, while the last ride is at 18:58. A Isernia to Agrigento train cost about 79.5 €. But how long is the train ride from Isernia to Agrigento? Your journey takes about 16 hours on average.