Isernia to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Alessandria every about 2 hours on average. If travelling with Trenitalia, you need to know the Isernia to Alessandria train schedule: the first train leaves at 06:45, while the last ride is at 15:10. A Isernia to Alessandria train cost about 64.8 €. But how long is the train ride from Isernia to Alessandria? Your journey takes about 9 hours on average.