Isernia to Alpignano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Alpignano every about 6 hours on average. If travelling with Trenitalia, you need to know the Isernia to Alpignano train schedule: the first train leaves at 06:45, while the last ride is at 20:34. A Isernia to Alpignano train cost about 97.0 €. But how long is the train ride from Isernia to Alpignano? Your journey takes about 11 hours on average.