Isernia to Ancona trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Ancona every about 2 hours on average. If travelling with Trenitalia, you need to know the Isernia to Ancona train schedule: the first train leaves at 06:45, while the last ride is at 11:16. A Isernia to Ancona train cost about 19.75 €. But how long is the train ride from Isernia to Ancona? Your journey takes about 7 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Isernia to Ancona and find low cost tickets starting from 20 €!