Isernia to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Caltanissetta Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Isernia to Caltanissetta train schedule: the first train leaves at 07:27, while the last ride is at 18:58. A Isernia to Caltanissetta train cost about 70.5 €. But how long is the train ride from Isernia to Caltanissetta? Your journey takes about 15 hours on average.