Isernia to Catania trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Catania Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Isernia to Catania train schedule: the first train leaves at 07:27, while the last ride is at 18:58. A Isernia to Catania train cost about 60.25 €. But how long is the train ride from Isernia to Catania? Your journey takes about 12 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Isernia to Catania and find low cost tickets starting from 20 €!