Isernia to Catania trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Catania Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Isernia to Catania train schedule: the first train leaves at 07:27, while the last ride is at 18:58. A Isernia to Catania train cost about 60.25 €. But how long is the train ride from Isernia to Catania? Your journey takes about 12 hours on average.