Isernia to Comiso trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Isernia to Comiso. Trains leave from Isernia and arrive at Comiso every about 12 hours on average. If travelling with Trenitalia, you need to know the Isernia to Comiso train schedule: the first train leaves at 18:58, while the last ride is at 18:58. A Isernia to Comiso train cost about 98.85 €. But how long is the train ride from Isernia to Comiso? Your journey takes about 18 hours on average.