Isernia to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Comiso every about 12 hours on average. If travelling with Trenitalia, you need to know the Isernia to Comiso train schedule: the first train leaves at 18:58, while the last ride is at 18:58. A Isernia to Comiso train cost about 98.85 €. But how long is the train ride from Isernia to Comiso? Your journey takes about 18 hours on average.