Isernia to Enna trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Enna every about 12 hours on average. If travelling with Trenitalia, you need to know the Isernia to Enna train schedule: the first train leaves at 18:58, while the last ride is at 18:58. A Isernia to Enna train cost about 68.85 €. But how long is the train ride from Isernia to Enna? Your journey takes about 16 hours on average.