Isernia to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Messina Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Isernia to Messina train schedule: the first train leaves at 08:25, while the last ride is at 18:58. A Isernia to Messina train cost about 52.95 €. But how long is the train ride from Isernia to Messina? Your journey takes about 11 hours on average.