Isernia to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Niscemi every about 6 hours on average. If travelling with Trenitalia, you need to know the Isernia to Niscemi train schedule: the first train leaves at 07:27, while the last ride is at 07:27. A Isernia to Niscemi train cost about 74.65 €. But how long is the train ride from Isernia to Niscemi? Your journey takes about 14 hours on average.