Isernia to Varese trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Varese every about 4 hours on average. If travelling with Trenitalia, you need to know the Isernia to Varese train schedule: the first train leaves at 06:45, while the last ride is at 17:25. A Isernia to Varese train cost about 107.7 €. But how long is the train ride from Isernia to Varese? Your journey takes about 8 hours on average.