Isernia to Vicenza trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Vicenza every about 2 hours on average. If travelling with Trenitalia, you need to know the Isernia to Vicenza train schedule: the first train leaves at 06:45, while the last ride is at 15:10. A Isernia to Vicenza train cost about 101.65 €. But how long is the train ride from Isernia to Vicenza? Your journey takes about 7 hours on average.