Manduria to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Oria and arrive at Milazzo every about 12 hours on average. If travelling with Trenitalia, you need to know the Manduria to Milazzo train schedule: the first train leaves at 08:13, while the last ride is at 08:13. A Manduria to Milazzo train cost about 63.55 €. But how long is the train ride from Manduria to Milazzo? Your journey takes about 12 hours on average.