Manduria to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Manduria to Niscemi. Trains leave from Oria and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Manduria to Niscemi train schedule: the first train leaves at 07:17, while the last ride is at 07:17. A Manduria to Niscemi train cost about 75.25 €. But how long is the train ride from Manduria to Niscemi? Your journey takes about 1 hour on average.