Manduria to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Oria and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Manduria to Niscemi train schedule: the first train leaves at 07:17, while the last ride is at 07:17. A Manduria to Niscemi train cost about 75.25 €. But how long is the train ride from Manduria to Niscemi? Your journey takes about 1 hour on average.